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研究成果

謝辞の記載についてAcknowledgement remarks

雑誌論文Papers

  1. Jinta Asami, Jae-Hyun Park, Yayoi Nomura, Chisa Kobayashi, Junki Mifune, Naito Ishimoto, Tomoko Uemura, Kehong Liu, Yumi Sato, Zhikuan Zhang, Masamichi Muramatsu, Takaji Wakita, David Drew, So Iwata, Toshiyuki Shimizu, Koichi Watashi, Sam-Yong Park, Norimichi Nomura, Umeharu Ohto
    Structural basis of hepatitis B virus receptor binding
    Nature Structural & Molecular Biology , 31 (2024)
    DOI: 10.1038/s41594-023-01191-5
    プレスリリース:
    A01:計画研究   A01 岩田 想  A01 野村 紀通  A01 朴 三用  
  2. *Maestre-Reyna M, Wang PH, Nango E, Hosokawa Y, Saft M, Furrer A, Yang CH, Gusti Ngurah Putu EP, Wu WJ, Emmerich HJ, Caramello N, Franz-Badur S, Yang C, Engilberge S, Wranik M, Glover HL, Weinert T, Wu HY, Lee CC, Huang WC, Huang KF, Chang YK, Liao JH, Weng JH, Gad W, Chang CW, Pang AH, Yang KC, Lin WT, Chang YC, Gashi D, Beale E, Ozerov D, Nass K, Knopp G, Johnson PJM, Cirelli C, Milne C, Bacellar C, Sugahara M, Owada S, Joti Y, Yamashita A, Tanaka R, Tanaka T, Luo F, Tono K, Zarzycka W, Muller P, Alahmad MA, Bezold F, Fuchs V, Gnau P, Kiontke S, Korf L, Reithofer V, Rosner CJ, Seiler EM, Watad M, Werel L, Spadaccini R, Yamamoto J, Iwata S, Zhong D, Standfuss J, Royant A, *Bessho Y, *Essen LO, *Tsai MD.
    Visualizing the DNA repair process by a photolyase at atomic resolution.
    J Science , 382 , 6674 , eadd7795 (2023)
    DOI: https://doi.org/10.1126/science.add7795
    プレスリリース: https://www.riken.jp/press/2023/20231201_2/index.html
    A01:計画研究  B01:計画研究   A01 岩田 想  A01 別所 義隆  B01 南後 恵理子  B01 大和田 成起  
  3. Han Ba Bui, Satoshi Watanabe, Norimichi Nomura, Kehong Liu, Tomoko Uemura, Michio Inoue, Akihisa Tsutsumi, Hiroyuki Fujita, Kengo Kinoshita, Yukinari Kato, So Iwata, Masahide Kikkawa, Kenji Inaba
    Cryo-EM structures of human zinc transporter ZnT7 reveal the mechanism of Zn2+ uptake into the Golgi apparatus
    Nature Communications , 14 , 4770 (2023)
    DOI: 10.1038/s41467-023-40521-5
    A01:計画研究   A01 岩田 想  A01 野村 紀通  
  4. Titouan Jaunet-Lahary, Tatsuro Shimamura, Masahiro Hayashi, Norimichi Nomura, Kouta Hirasawa, Tetsuya Shimizu, Masao Yamashita, Naotaka Tsutsumi, Yuta Suehiro, Keiichi Kojima, Yuki Sudo, Takashi Tamura, Hiroko Iwanari, Takao Hamakubo, So Iwata, Kei-ichi Okazaki, Teruhisa Hirai, Atsuko Yamashita
    Structure and mechanism of oxalate transporter OxlT in an oxalate-degrading bacterium in the gut microbiota
    Nature Communications , 14 , 1730 (2023)
    DOI: https://doi.org/10.1038/s41467-023-36883-5
    A01:計画研究   A01 岩田 想  A01 野村 紀通  
  5. Muna Al-Habsi, Kenji Chamoto, Ken Matsumoto, Norimichi Nomura, Baihao Zhang, Yuki Sugiura, Kazuhiro Sonomura, Aprilia Maharani, Yuka Nakajima, Yibo Wu, Yayoi Nomura, Rosemary Menzies, Masaki Tajima, Koji Kitaoka, Yasuharu Haku, Sara Delghandi, Keiko Yurimoto, Fumihiko Matsuda, So Iwata, Toshihiko Ogura, Sidonia Fagarasan, Tasuku Honjo
    Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice
    Science , 378 , 6618 , eabj3510 (2022)
    DOI: 10.1126/science.abj3510
    A01:計画研究   A01 岩田 想  A01 野村 紀通  
  6. Ryoji Suno, Yukihiko Sugita, Kazushi Morimoto, Hiroko Takazaki, Hirokazu Tsujimoto, Mika Hirose, Chiyo Suno-Ikeda, Norimichi Nomura, Tomoya Hino, Asuka Inoue, Kenji Iwasaki, Takayuki Kato, So Iwata, Takuya Kobayashi
    Structural insights into the G protein selectivity revealed by the human EP3-Gi signaling complex
    Cell Reports , 40 , 11 , 111323 (2022)
    DOI: 10.1016/j.celrep.2022.111323
    プレスリリース:
    A01:計画研究   A01 岩田 想  A01 野村 紀通  A01 日野 智也  
  7. Zhikuan Zhang, Norimichi Nomura, Yukiko Muramoto, Toru Ekimoto, Tomoko Uemura, Kehong Liu, Moeko Yui, Nozomu Kono, Junken Aoki, Mitsunori Ikeguchi, Takeshi Noda, So Iwata, Umeharu Ohto, Toshiyuki Shimizu
    Structure of SARS-CoV-2 membrane protein essential for virus assembly
    Nature Communications , 13 , 4399 (2022)
    DOI: 10.1038/s41467-022-32019-3
    プレスリリース:
    A01:計画研究   A01 岩田 想  A01 野村 紀通  
  8. Jinta Asami, Kanako Terakado Kimura, Yoko Fujita-Fujiharu, Hanako Ishida, Zhikuan Zhang, Yayoi Nomura, Kehong Liu, Tomoko Uemura, Yumi Sato, Masatsugu Ono, Masaki Yamamoto, Takeshi Noda, Hideki Shigematsu, David Drew, So Iwata, Toshiyuki Shimizu, Norimichi Nomura, Umeharu Ohto
    Structure of the bile acid transporter and HBV receptor NTCP
    Nature , 606 , 7916 , 1021 (1026)
    DOI: https://doi.org/10.1038/s41586-022-04845-4
    A01:計画研究  B01:計画研究   A01 岩田 想  A01 野村 紀通  B01 山本 雅貴  
  9. Jae-Hyun Park, Masashi Iwamoto, Ji-Hye Yun, Tomomi Uchikubo-Kamo, Donghwan Son, Zeyu Jin, Hisashi Yoshida, Mio Ohki, Naito Ishimoto, Kenji Mizutani, Mizuki Oshima, Masamichi Muramatsu, Takaji Wakita, Mikako Shirouzu, Kehong Liu, Tomoko Uemura, Norimichi Nomura, So Iwata, Koichi Watashi, Jeremy R. H. Tame, Tomohiro Nishizawa, Weontae Lee, Sam-Yong Park
    Structural insights into the HBV receptor and bile acid transporter NTCP
    Nature , 606 , 7916 , 1027-1031 (2022)
    DOI: https://doi.org/10.1038/s41586-022-04857-0
    プレスリリース: https://www.yokohama-cu.ac.jp/news/2022/20220518parksamyong.html
    A01:計画研究   A01 岩田 想  A01 野村 紀通  A01 朴 三用  
  10. Hosaka T, Nomura T, Kubo M, Nakane T, Fangjia L, Sekine SI, Ito T, Murayama K, Ihara K, Ehara H, Kashiwagi K, Katsura K, Akasaka R, Hisano T, Tanaka T, Tanaka R, Arima T, Yamashita A, Sugahara M, Naitow H, Matsuura Y, Yoshizawa S, Tono K, Owada S, Nureki O, Kimura-Someya T, Iwata S, *Nango E, *Shirouzu M.
    Conformational alterations in unidirectional ion transport of a light-driven chloride pump revealed using X-ray free electron lasers
    Proc Natl Acad Sci U S A , 119 , 9 , e2117433119 (2022)
    DOI: https://doi.org/10.1073/pnas.2117433119
    プレスリリース: https://www.kyoto-u.ac.jp/ja/research-news/2022-02-28-2
    A01:計画研究  B01:計画研究  C01:計画研究  A01:2020年公募班   A01 岩田 想  B01 南後 恵理子  B01 大和田 成起  C01 久保 稔  A01 保坂 俊彰  
  11. Rei Matsuoka, Roman Fudim, Sukkyeong Jung, Chenou Zhang, Andre Bazzone, Yurie Chatzikyriakidou, Carol V. Robinson, Norimichi Nomura, So Iwata, Michael Landreh, Laura Orellana, Oliver Beckstein, David Drew
    Structure, mechanism and lipid-mediated remodeling of the mammalian Na+/H+ exchanger NHA2
    Nature Structural & Molecular Biology , 29 , 2 , 108-120 (2022)
    DOI: 10.1038/s41594-022-00738-2
    A01:計画研究   A01 岩田 想  A01 野村 紀通  
  12. Koichiro E. Kishi, Yoon Seok Kim, Masahiro Fukuda, Masatoshi Inoue, Tsukasa Kusakizako, Peter Y. Wang, Charu Ramakrishnan, Eamon F.X. Byrne, Elina Thadhani, Joseph M. Paggi, Toshiki E. Matsui, Keitaro Yamashita, Takashi Nagata, Masae Konno, Sean Quirin, Maisie Lo, Tyler Benster, Tomoko Uemura, Kehong Liu, Mikihiro Shibata, Norimichi Nomura, So Iwata, Osamu Nureki, Ron O. Dror, Keiichi Inoue, Karl Deisseroth, Hideaki E. Kato
    Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine
    Cell , 185 , 4 , 672-689 (2022)
    DOI: 10.1016/j.cell.2022.01.007
    プレスリリース: https://www.u-tokyo.ac.jp/focus/ja/press/z0109_00034.html
    A01:計画研究   A01 岩田 想  A01 野村 紀通  A01 草木迫 司  A01 山下 恵太郎  
  13. Pan D, Oyama R, Sato T, Nakane T, Mizunuma R, Matsuoka K, Joti Y, Tono K, Nango E, Iwata S, Nakatsu T and *Kato H.
    Crystal structure of CmABCB1 multi-drug exporter in lipidic mesophase revealed by LCP-SFX
    IUCrJ. , 9 , 1 (2021)
    DOI: https://doi.org/10.1107/S2052252521011611
    プレスリリース: https://www.kyoto-u.ac.jp/ja/research-news/2021-12-23
    A01:計画研究  B01:計画研究   A01 岩田 想  A01 中津 亨  B01 南後 恵理子  
  14. *Katayama K, Suzuki K, Suno R, Kise R, Tsujimoto H, Iwata S, Inoue A, Kobayashi T & *Kandori H.
    Vibrational spectroscopy analysis of ligand efficacy in human M2 muscarinic acetylcholine receptor (M2R)
    Communications Biology , 4 , 1321 (2021)
    DOI: https://doi.org/10.1038/s42003-021-02836-1
    プレスリリース: https://www.nitech.ac.jp/news/press/2021/9297.html
    A01:計画研究  A01:2020年公募班   A01 岩田 想  A01 片山 耕大  
  15. 1. *Murakaw T, Suzuki M, Arima T, Sugahara M, Tanaka T, Tanaka R, Iwata S, Nango E, Tono K, Hayashi H, Fukui K, Yano T, Tanizawah K and *Okajima T.
    Microcrystal preparation for serial femtosecond X-ray crystallography of bacterial copper amine oxidase
    Acta Crystallographica Section F. , 77 (2021)
    DOI: https://doi.org/10.1107/S2053230X21008967
    A01:計画研究  B01:計画研究  A01:2020年公募班   A01 岩田 想  B01 南後 恵理子  A01 村川 武志  
  16. Dmitry Ghilarov, Satomi Inaba-Inoue, Piotr Stepien, Feng Qu, Elizabeth Michalczyk, Zuzanna Pakosz, Norimichi Nomura, Satoshi Ogasawara, Graham Charles Walker, Sylvie Rebuffat, So Iwata, Jonathan Gardiner Heddle, Konstantinos Beis
    Molecular mechanism of SbmA, a promiscuous transporter exploited by antimicrobial peptides
    Science Advances , 7 , 37 , abj5363 (2021)
    DOI: 10.1126/sciadv.abj5363
    プレスリリース: https://www.kyoto-u.ac.jp/ja/research-news/2021-09-09-0
    A01:計画研究   A01 岩田 想  A01 野村 紀通  
  17. Hiroyuki H. Okamoto, Hirotake Miyauchi, Asuka Inoue, Francesco Raimondi, Hirokazu Tsujimoto, Tsukasa Kusakizako, Wataru Shihoya, Keitaro Yamashita, Ryoji Suno, Norimichi Nomura, Takuya Kobayashi, So Iwata, Tomohiro Nishizawa, Osamu Nureki
    Cryo-EM structure of the human MT1–Gi signaling complex
    Nature Structural & Molecular Biology , 28 (2021)
    DOI: 10.1038/s41594-021-00634-1
    プレスリリース: https://www.s.u-tokyo.ac.jp/ja/info/7508/
    A01:計画研究  A01:2020年公募班   A01 岩田 想  A01 野村 紀通  A01 草木迫 司  A01 山下 恵太郎  A01 志甫谷 渉  
  18. Shingo Nojima, Yoko Fujita, Kanako Terakado Kimura, Norimichi Nomura, Ryoji Suno, Kazushi Morimoto, Masaki Yamamoto, Takeshi Noda, So Iwata, Hideki Shigematsu, Takuya Kobayashi
    Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein
    Structure , 29 , 3 , 252-260 (2021)
    DOI: 10.1016/j.str.2020.11.007
    A01:計画研究  B01:計画研究   A01 岩田 想  A01 野村 紀通  B01 山本 雅貴  
  19. Stephanie L. Neville, Jennie Sjöhamn, Jacinta A. Watts, Hugo MacDermott-Opeskin, Stephen J. Fairweather, Katherine Ganio, Alex Carey Hulyer, Aaron P. McGrath, Andrew J. Hayes, Tess R. Malcolm, Mark R. Davies, Norimichi Nomura, So Iwata, Megan L. O’Mara, Megan J. Maher, Christopher A. McDevitt
    The structural basis of bacterial manganese import
    Science Advances , 7 , 32 , eabg3980 (2021)
    DOI: 10.1126/sciadv.abg3980
    A01:計画研究   A01 岩田 想  A01 野村 紀通  
  20. Oda K, Nomura T, Nakane T, Yamashita K, Inoue K, Ito S, Vierock J, Hirata K, Maturana AD, Katayama K, Ikuta T, Ishigami I, Izume T, Umeda R, Eguma R, Oishi S, Kasuya G, Kato T, Kusakizako T, Shihoya W, Shimada H, Takatsuji T, Takemoto M, Taniguchi R, Tomita A, Nakamura R, Fukuda M, Miyauchi H, Lee Y, Nango E, Tanaka R, Tanaka T, Sugahara M, Kimura T, Shimamura T, Fujiwara T, Yamanaka Y, Owada S, Joti Y, Tono K, Ishitani R, Hayashi S, Kandori H, Hegemann P, Iwata S, Kubo M, Nishizawa T, Nureki O.
    Time-resolved serial femtosecond crystallography reveals early structural changes in channelrhodopsin
    elife , 23 , e62389 (2021)
    DOI: 10.7554/eLife.62389
    プレスリリース: https://www.s.u-tokyo.ac.jp/ja/press/2021/7284/
    A01:計画研究  B01:計画研究  C01:計画研究  A01:2020年公募班  C01:2020年公募班   A01 岩田 想  A01 草木迫 司  B01 南後 恵理子  B01 大和田 成起  C01 久保 稔  C01 木村 哲就  A01 志甫谷 渉  A01 片山 耕大  C01 林 重彦  
  21. Jin F, Sun M, Fujii T, Yamada Y, Wang J, Maturana AD, Wada M, Su S, Ma J, Takeda H, Kusakizako T, Tomita A, Nakada-Nakura Y, Liu K, Uemura T, Nomura Y, Nomura N, Ito K, Nureki O, Namba K, Iwata S, Yu Y, Hattori M
    The structure of MgtE in the absence of magnesium provides new insights into channel gating
    PLOS Biology , 19 , 4 , e3001231 (2021)
    DOI: 10.1371/journal.pbio.3001231
    A01:計画研究   A01 岩田 想  A01 野村 紀通  
  22. Matoba K, Kotani T, Tsutsumi A, Tsuji T, Mori T, Noshiro D, Sugita Y, Nomura N, Iwata S, Ohsumi Y, Fujimoto T, Nakatogawa H, Kikkawa M, Noda NN
    Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion
    Nature Structural & Molecular Biology , 27 , 1185-1193 (2020)
    DOI: 10.1038/s41594-020-00518-w
    プレスリリース: https://www.kyoto-u.ac.jp/ja/research-news/2020-10-28
    A01:計画研究   A01 岩田 想  A01 野村 紀通  
  23. Umeda R, Satouh Y, Takemoto M, Nakada-Nakura Y, Liu K, Yokoyama T, Shirouzu M, Iwata S, Nomura N, Sato K, Ikawa M, Nishizawa T, Nureki O
    Structural insights into tetraspanin CD9 function
    Nature Communications , 11 , 1606 (2020)
    DOI: 10.1038/s41467-020-15459-7
    A01:計画研究   A01 岩田 想  A01 野村 紀通  
  24. Asada H, Inoue A, Ngako Kadji FM, Hirata K, Shiimura Y, Im D, Shimamura T, Nomura N, Iwanari H, Hamakubo T, Kusano-Arai O, Hisano H, Uemura T, Suno C, Aoki J and Iwata S
    The crystal structure of angiotensin II type 2 receptor with endogenous peptide hormone
    Structure , 28 , 4 , 418-425 (2020)
    DOI: 10.1016/j.str.2019.12.003
    プレスリリース: https://www.kyoto-u.ac.jp/ja/research-news/2020-01-22-1
    A01:計画研究   A01 岩田 想  A01 野村 紀通  
  25. Kinjo T, Terai K, Horita S, Nomura N, Sumiyama K, Togashi K, Iwata S and Matsuda M.
    FRET-assisted photoactivation of flavoproteins for in vivo two-photon optogenetics
    Nature Methods , 16 , 1029-1036 (2019)
    DOI: 10.1038/s41592-019-0541-5
    プレスリリース: https://www.kyoto-u.ac.jp/ja/research-news/2019-09-10
    A01:計画研究   A01 岩田 想  A01 野村 紀通  
  26. Toyomoto M, Inoue A, Iida K, Denawa M, Kii I, Ngako Kadji FM, Kishi T, Im D, Shimamura T, Onogi H, Yoshida S, Iwata S, Aoki J, Hosoya T, Hagiwara M.
    S1PR3-G 12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation
    Cell Chem Biol. , 28 , 1-13 (2021)
    DOI: 10.1016/j.chembiol.2021.01.004.
    A01:計画研究   A01 岩田 想  
  27. Im D, Inoue A, Fujiwara T, Nakane T, Yamanaka Y, Uemura T, Mori C, Shiimura Y, Kimura KT, Asada H, Nomura N, Tanaka T, Yamashita A, Nango E, Tono K, Kadji FMN, Aoki J, Iwata S and Shimamura T.
    Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone
    Nat Commun. , 11 , 1 , 6442 (2020)
    DOI: 10.1038/s41467-020-20221-0
    プレスリリース: https://www.kyoto-u.ac.jp/ja/research-news/2020-12-24-2
    A01:計画研究  B01:計画研究   A01 岩田 想  A01 野村 紀通  B01 南後 恵理子  
  28. Wolff, A. M., Young, I. D., Sierra, R. G., Brewster, A. S., Martynowycz, M. W., Nango, E., Sugahara, M., Nakane, T., Ito, K., Aquila, A., Bhowmick, A., Biel, J. T., Carbajo, S., Cohen, A. E., Cortez, S., Gonzalez, A., Hino, T., Im, D., Koralek, J. D., Kubo, M., Lazarou, T. S., Nomura, T., Owada, S., Samelson, A. J., Tanaka, T., Tanaka, R., Thompson, E. M., van den Bedem, H., Woldeyes, R. A., Yumoto, F., Zhao, W., Tono, K., Boutet, S., Iwata, S., Gonen, T., Sauter, N. K., Fraser, J. S., Thompson, M. C.
    Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals.
    IUCrJ , 7 , 2 , 306-323 (2020)
    DOI: https://doi.org/10.1107/S205225252000072X
    A01:計画研究  B01:計画研究  C01:計画研究  C01:2020年公募班   A01 岩田 想  B01 南後 恵理子  B01 大和田 成起  C01 久保 稔  A01 日野 智也  

書籍Books

  1. Nomura N, Nomura Y, Sato Y and Iwata S
    Methods in Molecular Biology, Vol. 2247 “Multiprotein Complexes"
    Springer page: 77-103 (2021)
    A01:計画研究   A01 岩田 想  A01 野村 紀通  
  2. Nomura N, Nomura Y, Sato Y and Iwata S
    Methods in Enzymology, Vol. 629, "Tumor Immunology and Immunotherapy – Molecular Methods" (Edited by Lorenzo Galluzzi, Nils-Petter Rudqvist)
    Academic Press page: 383-399 (2019)
    A01:計画研究   A01 岩田 想  A01 野村 紀通  
  3. Raymond G. Sierra, Uwe Weierstall, Dominik Oberthuer, Michihiro Sugahara, Eriko Nango, So Iwata and Alke Meents.
    X-ray Free Electron Lasers - A Revolution in Structural Biology.
    Springer page: 109-184 (2019)
    A01:計画研究  B01:計画研究   A01 岩田 想  B01 南後 恵理子  

学会発表Presentations, Lectures

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